AMGN vs VRTX
Amgen (AMGN) and Vertex Pharmaceuticals (VRTX) compared side by side. Amgen (AMGN) is larger, with a market cap of $237.5B versus $132.8B for Vertex Pharmaceuticals, about 1.8 times the size. On trailing earnings, AMGN is cheaper at 27.3x versus 29.9x for VRTX.
Head to head
| Metric | AMGN | VRTX |
|---|---|---|
| Market cap | $237.5B | $132.8B |
| P/E (TTM) | 27.3x | 29.9x |
| Forward P/E | 17.9x | 25.7x |
| Revenue (TTM) | $38.1B | $12.6B |
| Revenue growth | 9.5% | 12.5% |
| Gross margin | 71.9% | 55.0% |
| Operating margin | 35.5% | 38.1% |
| Free cash flow | $10.2B | $3.8B |
| Dividend yield | 2.29% | None |
| 1-year return | +54.1% | +24.0% |
| 5-year return (annual) | +19.7% | +23.3% |
| Max drawdown | -78% | -92% |
| FI Handbook grade | B- | B |
Highlighted: the stronger figure on metrics where higher or lower is clearly better.
Growth of $10,000 (5 years, price only)
AMGN vs VRTX FAQ
Which is bigger, AMGN or VRTX?
Amgen (AMGN) is larger, with a market cap of $237.5B versus $132.8B for Vertex Pharmaceuticals, about 1.8 times the size.
Is AMGN or VRTX cheaper?
On trailing earnings, AMGN is cheaper at 27.3x versus 29.9x for VRTX. A lower P/E can reflect slower expected growth, so compare growth and margins too.
Which stock performed better over the past year, AMGN or VRTX?
AMGN returned +54.1% over the past year including dividends, versus +24.0% for VRTX, through October 23, 2026.
Which pays a higher dividend, AMGN or VRTX?
AMGN yields 2.29%; VRTX does not pay a dividend.
Full pages: Amgen · Vertex Pharmaceuticals